Naringin ingredients plant extract antioxidant,naringin is the major flavonoid glycoside in grapefruitand gives grapefruit juice its bitter taste. It is metabolized to the flavanone naringenin in humans. Both naringenin and hesperetin, which are the aglycones of naringin and hesperidin, occur naturally in citrus fruits.
Plant original: Citrus paradisi Macfadyen
Content Specifications: 98.0% Naringin Test by HPLC
Molecular Formula: C27H32O14
Molecular Mass: 580.54
CAS NO: 10236-47-2
Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug drug interactions in vivo. Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (esp. grapefruit) and other juices with medications is contraindicated.
Naringin, followed by rutin, was the most potent flavonoid inhibitor of VEGF release, which causes angiogenesis, out of 21 flavonoids.When Naringin is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes a naringin dihydrochalcone, a compound roughly 300-1800 times sweeter than sugar at threshold concentrations.
Naringin (and grapefruit) can interfere with certain drugs including calcium channel blockers, sedatives, cholesterol lowering drugs, caffeine and estrogen.
Naringin stimulates the effect of caffeine and could therefore increase its fat burning action.
Most studies have shown that a dose of 25 milligrams of naringin is enough to increase the bioavailability and half-life of certain nutrients and/or drugs consumed with it
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