Specification: 98.0% Apigenin Test by HPLC
CAS No: 520-36-5
Apigenin is an antioxidant plant flavanoid which contains anti-inflammatory and anticancer properties. It may induce apoptosis and may inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase.
Apigenin Is also known to be a MAP kinase inhibitor and a selective inhibitor of Protein Kinase 2 (CK2). Apigenin is capable of exerting diverse effects on a vast variety of molecular targets. Most effects appear to be mostly mediated through suppressing nitric oxide synthase-2 (NOS2), Hypoxia-inducible factor 1 α (HIF-1α), lipoxygenase, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression. Blocks proliferation of Wnt-1 transfected cells, dephosphorylates β-catenin and lowers levels of β-catenin and Dvi. Apigenin is an inhibitor of Casein Kinase, CYP19, CYP2C9, ERK and PKC.
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