1>Sources and Habitation
Apigenin (4,5,7-trihydroxyflavone), is a natural product belonging to the flavoneclass that is the aglycone of several naturally occurring glycosides.It is found in high amounts in several herbs including parsley, thyme, and peppermint.
It is is also found in a number of other herbs, including chamomile herb, Horsetail herb, lemon balm herb, perilla herb, vervain herb, and yarrow.
Red wine and tomato sauce contain this flavonoid.
2>Descriptions and Specifications of Product
Plant original: Apium graveolens var.dulce
Specifications: 98.0% Apigenin Test by HPLC
Molecular Formula: C15H10O5
Molecular Mass: 270.24
CAS No: 520-36-5
1>Function and Application
Apigenin is an antioxidant plant flavanoid which contains anti-inflammatory and anticancer properties. It may induce apoptosis and may inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase.
Apigenin Is also known to be a MAP kinase inhibitor and a selective inhibitor of Protein Kinase 2 (CK2). Apigenin is capable of exerting diverse effects on a vast variety of molecular targets. Most effects appear to be mostly mediated through suppressing nitric oxide synthase-2 (NOS2), Hypoxia-inducible factor 1 α (HIF-1α), lipoxygenase, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression. Blocks proliferation of Wnt-1 transfected cells, dephosphorylates β-catenin and lowers levels of β-catenin and Dvi. Apigenin is an inhibitor of Casein Kinase, CYP19, CYP2C9, ERK and PKC.
2> Safety Concerns
Apigenin seems to be very safe chemical, without any dangerous side effects, flavonoid can interact with chemotherapy drugs.
It is, by itself, a potent chemotherapeutic agent.
3> Dosage Information
For general health and well-being, doses found in multiple servings of fruits and vegetables is adequate.For anxiolytic effects, doses in the range of 3-10 mg/kg bodyweight are effective without sedation, and higher doses induce sedation in addition to reductions in anxiety.
The Information had not been evaluated by the Food and Drug Administration, only for reference
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